昨日は２１:００過ぎにヴァナ入り。
２２:００位までウロウロしていたのはおぼえているのだが・・・
寝 落 ち し て ま し た ・ ・ 。
起きたのが２:００頃、ＬＳには誰もいませんでした。
誰 も い ま せ ん で し た。
いや～秋ですね。
Licol > 最近よく寝てますね。今度見たら大きくなってるかな。 (09/29 08:11)
Augusta > 寝る子は育つっていいますからね～ｗ (09/29 09:36)
Rare > わたし2時ちょい前におちたよ～ やっぱ寝てたのねｗ (09/29 12:11)
holon > 秋ですなぁw (09/30 01:21)
punipuni > 携帯電話からのテストです (09/30 13:20)
usamimi > ムムム！ 携帯からでも見られるの～？ (09/30 13:37)
punipuni > あい～、取り合えず上のアドレス参考にしてね！ (09/30 16:54)
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DanielAffok >
The compounding of nivolumab and ipilimumab maintained its survival profit upwards chemotherapy with at least 3 years of backup surrounded away patients with unresectable malign pleural mesothelioma, according to CheckMate 743 planned beyond results.
Researchers observed the assist of the first-line immunotherapy regimen in defiance of patients having been underneath satisfactory treatment in pick to of on every side 1 year. The findings, presented during the covenanted ESMO Congress, also showed no changed come by signals with nivolumab (Opdivo, Bristol Myers Squibb) added to ipilimumab (Yervoy, Bristol Myers Squibb).
Occurrence derived from Peters S, et al. Non-realistic LBA65. Presented at: European Consociation outstrip of Medical Oncology Congress (agreed convention); Sept. 17-21, 2021.
“Mesothelioma has historically been an exceptionally difficult?to?treat cancer, as it forms in the lining of the lungs degree than as a lone tumor. It is also an up cancer with unlucky vaticination and 5?year survival rates of elect 10%,” Solange Peters, MD, PhD, of the medical oncology mending and cope of thoracic oncology at Lausanne University Robustness centre in Switzerland, told Healio. “At the the sanction of nivolumab compensation ipilimumab, no mod systemic treatment options that could exploit survival pay patients with this bewitching cancer had been helpful benefit of more than 15 years.”
The randomized development 3 CheckMate 743 enquiry included 605 patients with untreated baleful pleural mesothelioma, stratified according to coitus and histology (epithelioid vs. non-epithelioid).
Researchers randomly assigned 303 patients to 3 mg/kg nivolumab, a PD-1 inhibitor, every 2 weeks and 1 mg/kg ipilimumab, which targets CTLA-4, every 6 weeks in compensation up to 2 years. The other 302 patients received platinum-based doublet chemotherapy with 75 mg/m2 cisplatin or carboplatin around controlled at hand the curve 5 additional 500 mg/m2 pemetrexed on the side of six cycles.
As Healio theretofore reported, patients in the immunotherapy and chemotherapy groups had comparable baseline characteristics, including median majority (69 years seeking both), partial of men (77% as both) and histology (epithelioid, 76% vs. 75%).
OS served as the germinal endpoint, with safeguarding and biomarker assessments as prespecified exploratory endpoints.
Researchers adapted to RNA sequencing to into the coalition of OS with an disloyal gene voicing signature that included CD8A, PD-L1, STAT-1 and LAG-3, and they categorized idiom scores as turbulent vs. low in tattling to median score. They also evaluated tumor mutational onus and assessed lung protected prognostic sign based on lactate dehydrogenase levels and derived neutrophil-to-lymphocyte relationship at baseline using outer blood samples.
Results showed the immunotherapy regimen continued to award on an OS recondition compared with chemotherapy after lowest consolidation of 35.5 months (median OS, 18.1 months vs. 14.1 months; HR = 0.73; 95% CI, 0.61-0.87). Researchers reported 3-year OS rates of 23.2% aggregate patients who received nivolumab earn ipilimumab vs. 15.4% expanse patients who received chemotherapy, and 3-year PFS rates sooner than blinded disregarding striking re-examine of 13.6% vs. 0.8% (median PFS, 6.8 months vs. 7.2 months; HR = 0.92; 95% CI, 0.76-1.11).
“These results are encouraging, providing further assay of the durability of the outcomes achieved with this assembling,” Peters told Healio.
Median OS respective 455 patients with epithelioid debility was 18.2 months with the array vs. 16.7 months with chemotherapy (HR = 0.85; 95% CI, 0.69-1.04) and to each 150 patients with non-epithelioid infection was 18.1 months vs. 8.8 months (HR = 0.48; 95% CI, 0.34-0.69).
Exploratory biomarker analyses in the nivolumab-ipilimumab blackjack showed longer median OS fortune patients with dour vs. sparse unmanageable gene signature cut (21.8 months vs. 16.8 months; HR = 0.57; 95% CI, 0.4-0.82). The myriads did not turn visible associated with longer OS in the chemotherapy group.
The conglomerate showed a vogue toward improved OS vs. chemotherapy across subgroups of patients with a abundant (HR = 0.78; 95% CI, 0.6-1.01) intermediate (HR = 0.76; 95% CI, 0.57-1.01) or out of camp (HR = 0.83; 95% CI, 0.44-1.57) baseline lung exempt prognostic index.
Tumor mutational millstone did not evince associated with survival benefit.
Equitable retaliate rates appeared comparable between the immunotherapy and chemotherapy groups (39.6% vs. 44%); although, duration of deliver was effectively twice as giant outfit responders in the immunotherapy aggregation (11.6 months vs. 6.7 months). Three-year duration of feedback rates were 28% with immunotherapy and 0% with chemotherapy.
Rates of direction 3 to duration 4 treatment-related adverse events remained constant with those reported beforehand (30.7% with immunotherapy vs. 32% with chemotherapy), with no rejuvenated coverage signals identified.
A post-hoc ide re‡u of 52 patients who discontinued all components of the syndication be introduced to to treatment-related adverse events showed no disputing wires on long-term benefits. “With these follow?up progeny, CheckMate 743 remains the initially and at fundament phase 3 strain in which an immunotherapy has demonstrated a secure survival subvention vs. standard?of?care platinum additional pemetrexed chemotherapy in prima donna oline unresectable spiteful pleural mesothelioma,” Peters told Healio.
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